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PRISMA 2020 flow diagram. CUAs, congenital uterine anomalies; PCOS, polycystic ovary syndrome.

Journal: Human Reproduction Open

Article Title: Is polycystic ovary syndrome associated with uterine malformations? A systematic review using Bradford Hill’s causality framework

doi: 10.1093/hropen/hoag005

Figure Lengend Snippet: PRISMA 2020 flow diagram. CUAs, congenital uterine anomalies; PCOS, polycystic ovary syndrome.

Article Snippet: Gradient , Assigned if the increasing level of exposure to androgen and/or AMH levels corresponds to a higher risk of CUAs or specific types of CUAs in patients with PCOS , Aslan et al. (2022) , In the PCOS subgroup, free testosterone levels were positively correlated with the presence of CUA ( P = 0.03). Using a threshold of 2.025 ng/ml, free testosterone levels predicted CUAs, with an AUC of 0.765 (95% CI 0.569–0.960, P = 0.03) , Assigned , 2b , High .

Techniques:

Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and intratesticular testosterone level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.

Journal: Frontiers in Endocrinology

Article Title: First in class monoclonal antibody potentiating human follicle stimulating hormone activity improves spermatogenesis in azoospermic rodent models

doi: 10.3389/fendo.2025.1668945

Figure Lengend Snippet: Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and intratesticular testosterone level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.

Article Snippet: After testicular sperm reserve assessment, the sample is used to quantify the intratesticular testosterone levels using a commercially available kit from Cayman (Interchim, Montluçon, France).

Techniques: Cell Counting